Marenostrumtech Unlock the power of a healthy mind
A unique methoxyflavonoid complex derived from upcycled citrus, standardized and GMP-produced, with in vitro neuroprotective evidence for next-generation brain health formulations.
A next-generation citrus ingredient for brain health
MethoxyMemory® is a next-generation nutraceutical ingredient designed to support brain health. It is based on an exclusive citrus-derived antioxidant complex naturally rich in methoxyflavonoids.
Citrus flavonoids are increasingly recognized for their role in supporting brain health. Their neuroprotective properties are linked to their ability to reduce oxidative stress and inflammation, helping protect neurons and maintain cognitive function.
Obtained through the upcycling of citrus by-products, it transforms an underutilized side stream into a high-value nutraceutical ingredient, combining sustainability and GMP manufacturing.
Upcycling citrus into cognitive value
Made from upcycled citrus by-products, this ingredient gives new value to materials that would otherwise go to waste, creating a sustainable solution for brain health applications.
Citrus fruits
→Processing industry
→Upcycled by-products
→Methoxyflavonoid extraction
→Brain health ingredient
→What makes MethoxyMemory® different
Naturally derived
Naturally rich in antioxidant methoxyflavonoids.
Upcycled origin
Giving new value to citrus by-products through upcycling.
Sustainably produced
Produced using environmentally responsible practices.
GMP-certified
Manufactured under GMP standards to ensure consistent quality and safety.
Supported by in vitro evidence
Backed by studies exploring its neuroprotective potential.
Rich antioxidant profile
Featuring a distinctive composition of methoxyflavonoids and other antioxidant compounds.
A fast-growing brain health market
The global brain health and cognitive support market continues to expand, driven by growing demand for natural, science-backed solutions.
MethoxyMemory® is designed to meet the growing demand for evidence-based ingredients in the nootropic and healthy aging categories. Its sustainable origin and distinctive methoxyflavonoid profile make it a versatile option for innovative formulations.
The cognitive support market is expected to continue growing steadily over the coming years, driven by increasing consumer interest in healthy aging and cognitive performance.
Why methoxyflavonoids matter for brain health
A carefully standardized composition of polyphenols, flavonoids, and methoxyflavonoids designed to deliver a distinctive antioxidant profile for cognitive health formulations.
Gallic acid
A naturally occurring polyphenol that contributes to the extract’s antioxidant profile and is widely studied for its biological activity.
Naringin & Narirutin
Characteristic citrus flavanones known for their antioxidant properties and their role in supporting cellular protection.
Nobiletin
The principal methoxyflavonoid in the extract and the key marker used for standardization, contributing to its distinctive phytochemical profile.
Methoxyflavonoids are flavonoids containing methoxy groups (–OCH₃). This structural feature is associated with improved stability and bioavailability and may contribute to enhanced biological activity compared with non-methoxylated flavonoids.
Nobiletin — the principal methoxyflavonoid
The extract is standardized to nobiletin, a polymethoxylated flavonoid naturally found in citrus. Its multiple methoxy groups (–OCH₃) are associated with improved stability and bioavailability compared with non-methoxylated flavonoids.
Nobiletin is widely studied for its antioxidant and neuroprotective potential.
Oxidative stress modulation
Supports antioxidant defenses by helping reduce oxidative stress and reactive oxygen species (ROS).
Mitochondrial support
Helps maintain mitochondrial function and cellular energy metabolism under oxidative conditions.
Neuroprotective signaling
Associated with molecular pathways involved in neuronal survival and resistance to oxidative damage.
Synaptic function
Supports the expression of markers related to synaptic integrity and neuronal communication.
Cognitive support
Promotes pathways associated with neuroplasticity and healthy cognitive function.
Designed to support memory, attention and cognitive health
Antioxidant protection
Rich in citrus methoxyflavonoids that help support antioxidant defenses and protect cells from oxidative stress.
Memory & learning
Supports pathways associated with memory and learning, including those related to neuroplasticity and BDNF signaling.
Mental energy & clarity
Supports healthy neuronal function and cellular energy metabolism, helping maintain mental performance.
Overall brain vitality
Provides antioxidant and neuroprotective support for formulations focused on long-term brain health and cognitive well-being.
In vitro evidence after simulated digestion
An in vitro study* using a simulated gastrointestinal digestion model demonstrated that the bioaccessible fraction retained measurable antioxidant activity and modulated markers associated with neuronal function after digestion.
Antioxidant activity
Intracellular ROS reduced ≈80% after simulated digestion (TBHP challenge), indicating retained antioxidant capacity.
Neuronal activity
Increased BDNF (≈+40%) and DRD2 (≈+25%) mRNA, markers associated with neuroplasticity and neurotransmitter signaling.
Neuronal survival
Cell viability preserved ≈+30% in the neuronal model after simulated digestion.
Neuroprotective biomarkers
Upregulation of BCL2 (≈+76%), BDNF, SYN1 and DLG4, markers related to neuronal survival and synaptic integrity.
How it was tested
A dynamic in vitro digestion model simulates gastrointestinal processing to generate the bioaccessible fraction of the ingredient. This fraction is then evaluated in a neuronal cell model to assess its biological activity after digestion.
Intake
The ingredient enters the simulated gastrointestinal digestion system.
→Digestion
Dynamic gastrointestinal digestion is reproduced under physiologically relevant conditions.
→Bioaccessible fraction
The soluble intestinal fraction is collected after digestion for biological evaluation.
→Brain effect
The bioaccessible fraction is tested in a neuronal cell model to assess antioxidant and neuroprotection-associated responses.
Biocompatibility
Confirmed compatibility with the neuronal cell model used throughout the study.
Antioxidant capacity (ROS)
Reduced intracellular reactive oxygen species (ROS) following simulated digestion in the neuronal model.
Neurotransmitter signaling
Increased expression of markers associated with neuroplasticity and neurotransmitter signaling, including BDNF and DRD2.
Neuroprotective biomarkers
Assessment of cell viability and biomarkers related to neuronal function and synaptic integrity, including BDNF, SYN1 and DLG4.
Data are based on in vitro studies and reflect ingredient-level findings under experimental conditions. Values are indicative and should not be interpreted as clinical outcomes. This information is intended for B2B use only and does not constitute a consumer health claim. Final product claims remain the responsibility of the manufacturer and must comply with applicable regulations.
Bring evidence-based cognitive science to your formulation
Get the full technical datasheet and request a sample for your lab trials.
Where MethoxyMemory® fits
A versatile ingredient suitable for a wide range of delivery formats, from capsules and sachets to functional foods and beverages, supporting innovation in the growing brain health category.
Dietary supplements
Suitable for daily food supplement formulations targeting cognitive health and healthy aging.
Nootropic formulations
Designed for formulations focused on cognitive performance, memory, and healthy brain function.
Functional nutrition
Suitable for functional foods and beverages with a cognitive wellness and antioxidant positioning.
Ready to formulate with MethoxyMemory®?
Our commercial team will help you fit it into your next brain health product.
Reference technical data
Indicative specifications for formulation. Full analytical detail and certificates of analysis are provided in the technical datasheet.
Key phytochemical markers
End-to-end expertise: from source to ingredient
MethoxyMemory® is developed and manufactured in-house by Marenostrumtech, combining dedicated R&D, GMP manufacturing, and end-to-end traceability from upcycled citrus by-products to the finished ingredient.
GMP manufacturing plant
Manufactured in a GMP-certified facility to ensure quality, safety, and batch-to-batch consistency.
In-house R&D capability
Supported by dedicated in-house research and development to advance ingredient innovation and scientific validation.
Full traceability
End-to-end traceability from upcycled citrus by-products to the finished ingredient, supporting transparency and responsible sourcing.
Quality, safety and consistency in every batch
MethoxyMemory® is manufactured in our GMP-certified facility, ensuring consistent quality, safety, and traceability from upcycled citrus by-products to the finished ingredient.
MethoxyMemory® is a Marenostrumtech ingredient — science-driven biodynamic extracts from Alicante, Spain. Visit Marenostrumtech
A trusted international distribution network
MethoxyMemory® is represented by selected distribution partners across key markets.
Start formulating with MethoxyMemory®
Tell us about your project and our commercial team will get back to you with the technical datasheet and a sample.
Full technical datasheet
Specifications, standardization, certificates and formulation guidance.
Ingredient sample
Request material for your lab trials and proof-of-concept work.
Direct line to our team
Your request is sent straight to the Marenostrumtech commercial team.